When a group of patients, with ROS1 positive cancer, or ROS1+ cancer, came to ALCF to ask for help we immediately said yes.
ROS1+ cancer occurs when a gene called ROS1 fuses with a nearby gene and swaps pieces of DNA. Thus far over 20 different genes have been found to fuse with ROS1 and drive ROS1+ cancer. When this happens, the ROS protein encoded by the ROS1 gene becomes abnormal. The actions of this abnormal protein drive the cell to behave like cancer: live forever, make many copies of itself, invade neighboring cells, and ultimately travel through the bloodstream and lymph to create tumors in other parts of the body.
ROS1 cancer tends to be aggressive, and can spread to the bones and brain.
ALCF funded a research study to collect ROS1+ cancer patients’ histories using an online survey and analyze commonalities that might have contributed to the development of their cancer.
Now, ALCMI is leading a project (funded by ALCF and ROS1ders) to create new ROS1 cancer models from fresh biopsy and surgery specimens donated by ROS1ders. The tumor tissue will be implanted into specialized mice in order to create animals with human cancer cells that keep dividing and growing over time in order to study the biology of cancer and to test cancer treatments.
In order to continue to study ROS1 + cancers and make progress, we need to continue to raise funds. Please consider donating to the ROS1ders and help them in their quest to find their next treatment and save their lives.
How to Contribute
There are several ways in which you can contribute to this effort:
Spread the word about this effort. Tell everyone about this thriving patient community! You might help a ROS1+ cancer patient find a community of other patients like them, their safe place where they can share their experiences and learn from those of others. Share this page on:
Advocate for more research on cancer, in general, and on ROS1+ cancers specifically. ROS1+ cancer is an understudied molecular subset of all cancers. It comprises 1-2% of all cancer types it is diagnosed in. Therefore, there isn’t much going on for this rare disease subset. We need more research to understand what drives these cancers, and how we can stop them from growing and proliferating.
Donate now to create a ROS1 bio-repository that will house bio-specimens from ROS1+ cancer patients, and will help researchers understand what drives this disease.
Fundraise. Given this is a patient-driven, patient-focused ROS1 positive cancer research effort, several ROS1ers have come together to fundraise for this project. The Addario Lung Cancer Foundation has set up a restricted account especially earmarked for this project. All monies raised by the ROS1ers’ efforts will be added to this account and used to fund research efforts specifically on ROS1-positive cancers.
Learn more about this type of cancer and how the ROS1ders are working with the Addario Lung Cancer Foundation to advance the science and aid the fight against all ROS1+ cancers by watching the video at left.
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